After an affirmative opinion verb (creer, pensar, parecer), use the indicative: the idea is asserted as true. Negate that verb and the following clause switches to the subjunctive, because the idea is no longer asserted. A plain question does NOT force the switch - "¿Crees que...?" normally keeps the indicative, and the subjunctive is only an optional, marked choice when the speaker wants to signal extra doubt.
Examples
- Creo que el problema es estructural.
- I think the problem is structural. (affirmative - indicative)
- No creo que el problema sea estructural.
- I don't think the problem is structural. (negated - subjunctive)
- ¿Crees que el problema es estructural?
- Do you think the problem is structural? (neutral question - indicative is the default)
- ¿Crees que sea estructural, después de todo lo que hemos visto?
- Do you really think it's structural, after everything we've seen? (marked question - subjunctive signals the speaker's own doubt)
The mistake to avoid
Two slips: keeping the indicative after the negative ("No creo que es" should be "No creo que sea"), and over-applying the rule to questions, where "¿Crees que es...?" - not "¿Crees que sea...?" - is the neutral default.
Where this fits in
Sociedad y opinión, Spanish B2: Debate abstract social topics in a formal register, using connectives of contrast and concession, opinion frames, and hedging strategies.